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Valentin Dinu
Assoc Professor
Faculty
DTPHX Campus
Mailcode
9020
Biography
Valentin Dinu joined Arizona State University in 2007. He holds a doctorate in computational biology and bioinformatics from Yale University and an A.B. in mathematics and physics from Harvard University. He also worked in industry as a quantitative financial modeler, software engineer and consultant.
His research interests are the assessment, improvement, and development of computational approaches, software applications and databases that will facilitate the management, integration and analysis of diverse sources of biomedical information. Some of Valentin Dinu's teaching and research areas include 1) the use of biological domain knowledge to supplement statistical analysis and data mining methods to identify genes and pathways associated with disease, and 2) the exploration of database modeling approaches for managing large and heterogeneous data sets from both clinical and biosciences domains. Application domains include next generation sequencing (NGS), genome wide association studies (GWAS), and immunosignature protein arrays.
Education
- Ph.D. Computational Biology and Bioinformatics, Yale University
- A.B. Mathematics and Physics, Harvard University
Research Interests
Valentin Dinu's research interests are the assessment, improvement, and development of computational approaches, software applications and databases that will facilitate the management, integration and analysis of diverse sources of biomedical information. Some of Valentin Dinu's teaching and research areas include 1) the use of biological domain knowledge to supplement statistical analysis and data mining methods to identify genes and pathways associated with disease, and 2) the exploration of database modeling approaches for managing large and heterogeneous data sets from both clinical and biosciences domains. Application domains include next generation sequencing (NGS), genome wide association studies (GWAS), and immunosignature protein arrays.
Related Links:
Publications
- Valentin Dinu, Perry Miller, Hongyu Zhao. Evidence for association between multiple complement pathway genes and AMD. Genetic Epidemiology (2007).
- Valentin Dinu, Prakash Nadkarni. Guidelines for the effective use of entity-attribute-value modeling for biomedical databases. International Journal of Medical Informatics (2007).
- Valentin Dinu, Zhao Hongyu, Perry Miller. Integrating domain knowledge with statistical and data mining methods for high-density genomic SNP disease association analysis. Journal of Biomedical Informatics (2007).
- Valentin Dinu, Prakash Nadkarni, Cindy Brandt. Pivoting approaches for bulk extraction of Entity-Attribute-Value data. Computer Methods and Programs in Biomedicine (2006).
Research Activity
- Dinu,Valentin*. Idiopathic Subglottic Stenosis Tissue and Deep Sequencing Study. ASU-Mayo Seed Grant(1/1/2013 - 12/31/2014).
- Dinu,Valentin*, Dinu,Valentin*, Labaer,Joshua. Whole Genome and Transcriptome Sequencing Analyses of Desmoplastic Small Round Cell Tumors. PHX. CHILDREN'S HOSP(9/1/2012 - 9/30/2015).
- Coletta,Dawn*, Dinu,Valentin, Mandarino,Lawrence, Meyer,Christian. Epigenetics and the Origin of Muscle Insulin Resistance in Humans. HHS-NIH-NIDDK(8/6/2012 - 7/31/2017).
- Dinu,Valentin*. BOA: a Server of Integrated Biological Reference Annotations for Clinical and Life Science 'omics' Application. ASU-Mayo Seed Grant(1/1/2012 - 11/30/2013).
- Dinu,Valentin*, Labaer,Joshua. Next Generation Genome Sequencing of Desmoplastic Small Round Cell Tumors. PHX CHLDRN'S HOSPITAL(8/23/2011 - 8/22/2013).
- Dinu,Valentin*. NIH Sequence Data - Bioinformatics Service. HHS-NIH-NLM(1/1/2011 - 12/31/2011).
- Labaer,Joshua*, Cheatham,Robert Lee, Dinu,Valentin, Dinu,Valentin, Magee,Dewey Mitchell, Wallstrom,Garrick L, Wallstrom,Garrick L. Integrated Biodosimetry System (IBiS) for High Throughput Medical Care After Radiologic and Nuclear Events. BARDA(12/17/2009 - 1/31/2016).
- Dinu,Valentin*. Computational Design of Peptide Inhibitors for Class B G Protein-coupled Receptors. MAYO CLINIC SCOTTSDALE(1/1/2001 - 12/31/2010).
Courses
| Fall 2018 | |
|---|---|
| Course Number | Course Title |
| BMI 461 | Advanced Topics in BMI I |
| BMI 484 | Internship |
| BMI 492 | Honors Directed Study |
| BMI 502 | Foundations BMI Methods I |
| BMD 502 | Foundations BMI Methods I |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 584 | Internship |
| BMI 590 | Reading and Conference |
| BMI 593 | Applied Project |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| BMI 799 | Dissertation |
| Summer 2018 | |
|---|---|
| Course Number | Course Title |
| BMI 484 | Internship |
| BMI 584 | Internship |
| BMI 595 | Continuing Registration |
| BMI 792 | Research |
| Spring 2018 | |
|---|---|
| Course Number | Course Title |
| BMI 484 | Internship |
| BMI 493 | Honors Thesis |
| BMI 499 | Individualized Instruction |
| BMD 550 | Translational Bioinformatics |
| BMI 550 | Translational Bioinformatics |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 593 | Applied Project |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| BMI 799 | Dissertation |
| Fall 2017 | |
|---|---|
| Course Number | Course Title |
| BMI 484 | Internship |
| BMI 492 | Honors Directed Study |
| BMI 499 | Individualized Instruction |
| BMI 502 | Foundations BMI Methods I |
| BMD 502 | Foundations BMI Methods I |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 593 | Applied Project |
| BMI 595 | Continuing Registration |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| BMI 799 | Dissertation |
| Summer 2017 | |
|---|---|
| Course Number | Course Title |
| BMI 484 | Internship |
| BMI 584 | Internship |
| BMI 593 | Applied Project |
| BMI 595 | Continuing Registration |
| BMI 792 | Research |
| BMI 799 | Dissertation |
| Spring 2017 | |
|---|---|
| Course Number | Course Title |
| BMD 550 | Translational Bioinformatics |
| BMI 550 | Translational Bioinformatics |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 590 | Reading and Conference |
| BMI 592 | Research |
| BMI 593 | Applied Project |
| BMI 595 | Continuing Registration |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| BMI 799 | Dissertation |
| Fall 2016 | |
|---|---|
| Course Number | Course Title |
| BMD 502 | Foundations BMI Methods I |
| BMI 502 | Foundations BMI Methods I |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 593 | Applied Project |
| BMI 595 | Continuing Registration |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| Summer 2016 | |
|---|---|
| Course Number | Course Title |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| Spring 2016 | |
|---|---|
| Course Number | Course Title |
| BMI 592 | Research |
| BMI 593 | Applied Project |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| BMI 799 | Dissertation |
| Fall 2015 | |
|---|---|
| Course Number | Course Title |
| BMI 592 | Research |
| BMI 593 | Applied Project |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| Summer 2015 | |
|---|---|
| Course Number | Course Title |
| BMI 790 | Reading and Conference |
| BMI 792 | Research |
| Spring 2015 | |
|---|---|
| Course Number | Course Title |
| BMI 592 | Research |
| BMI 790 | Reading and Conference |
| BMI 799 | Dissertation |
| Fall 2014 | |
|---|---|
| Course Number | Course Title |
| BMI 101 | Introduction to Bioinformatics |
| BMI 560 | Teachng Biomedical Informatics |
| BMI 790 | Reading and Conference |
| Spring 2014 | |
|---|---|
| Course Number | Course Title |
| BMI 550 | Translational Bioinformatics |
Presentations
- Valentin Dinu. Pathway-based Analysis of Association between High Density Genomic Loci and Disease. Neuroscience-Neurogenomics Collaborative Colloquium Series (UA, TGen, ASU) (Nov 2008).
- Jeffrey Kriseman, Tarek Saleh, Valentin Dinu. Next Generation Translational Bioinformatics Research Toolkit. Translational Genomics Research Institute Retreat (May 2008).
- Dinu, Valentin. Pathway-based Analysis of Association between Genomic Loci and Disease. Mayo Clinic Seminar Series (Apr 2008).
- Dinu, Valentin. Informatics Approaches to Translational Research: Management and Analysis of Clinical and High Density Genomic Data. (May 2007).
- Dinu, Valentin. Integrating Domain Knowledge with Statistical and Data Mining Methods for High Density Genomic SNP Disease Association Analysis. (Apr 2007).
- Dinu, Valentin. Pathway/SNP: Integrating Domain Knowledge with Statistical and Data Mining Methods for High Density Genomic SNP Disease Association Analysis. Genome-Wide Association Studies: Design and Analysis Conference (Oct 2006).
- Dinu, Valentin. Pathway-based Analysis of Association between Genomic Loci and Disease. NLM Informatics Training Conference (Jun 2006).
Honors/Awards
- Excellence in Teaching Award (1999)
- Magna Cum Laude with Highest Honors college graduate (2000)
- PhD funded by National Library of Medicine Biomedical Informatics Training Grant (2004-2007)
- ASU/Mayo Clinic Partnership for Collaborative Research Seed Grant Award (2010)
Service
- Human Genetics, Research Article Reviewer (2008 - Present)
- BMI/BMS Colloquium Series Committee, Member (2008 - Present)
- Journal of Biomedical Informatics, Research Article Reviewer (2008 - Present)
- BMI Undergraduate Curriculum Committee, (2007 - Present)
- BMI Graduate Curriculum Committee, (2007 - Present)
- EURASIP Journal on Bioinformatics and Systems Biology, Research Article Reviewer (2007 - Present)
- BMI Adjunct/Affiliate Committee, Chair (2008 - 2008)