Valentin Dinu

Assoc Professor

Faculty

DTPHX Campus

Mailcode

9020

Biodesign Center for Personalized Diagnostics

Associate Faculty

Faculty

DTPHX Campus

Mailcode

9020

Bio
Research
Teaching
Public Work

Biography

Valentin Dinu joined Arizona State University in 2007. He holds a doctorate in computational biology and bioinformatics from Yale University and an A.B. in mathematics and physics from Harvard University. He also worked in industry as a quantitative financial modeler, software engineer and consultant.

His research interests are the assessment, improvement, and development of computational approaches, software applications and databases that will facilitate the management, integration and analysis of diverse sources of biomedical information. Some of Valentin Dinu's teaching and research areas include 1) the use of biological domain knowledge to supplement statistical analysis and data mining methods to identify genes and pathways associated with disease, and 2) the exploration of database modeling approaches for managing large and heterogeneous data sets from both clinical and biosciences domains. Application domains include next generation sequencing (NGS), genome wide association studies (GWAS), and immunosignature protein arrays.

CV

DinuCV_201902.pdf

Education

Ph.D. Computational Biology and Bioinformatics, Yale University
A.B. Mathematics and Physics, Harvard University

Research Interests

Valentin Dinu's research interests are the assessment, improvement, and development of computational approaches, software applications and databases that will facilitate the management, integration and analysis of diverse sources of biomedical information. Some of Valentin Dinu's teaching and research areas include 1) the use of biological domain knowledge to supplement statistical analysis and data mining methods to identify genes and pathways associated with disease, and 2) the exploration of database modeling approaches for managing large and heterogeneous data sets from both clinical and biosciences domains. Application domains include next generation sequencing (NGS), genome wide association studies (GWAS), and immunosignature protein arrays.

Related Links:

Publications

Valentin Dinu, Perry Miller, Hongyu Zhao. Evidence for association between multiple complement pathway genes and AMD. Genetic Epidemiology (2007).
Valentin Dinu, Prakash Nadkarni. Guidelines for the effective use of entity-attribute-value modeling for biomedical databases. International Journal of Medical Informatics (2007).
Valentin Dinu, Zhao Hongyu, Perry Miller. Integrating domain knowledge with statistical and data mining methods for high-density genomic SNP disease association analysis. Journal of Biomedical Informatics (2007).
Valentin Dinu, Prakash Nadkarni, Cindy Brandt. Pivoting approaches for bulk extraction of Entity-Attribute-Value data. Computer Methods and Programs in Biomedicine (2006).

Research Activity

Dinu,Valentin*. Idiopathic Subglottic Stenosis Tissue and Deep Sequencing Study. ASU-Mayo Seed Grant(1/1/2013 - 12/31/2014).
Dinu,Valentin*, Dinu,Valentin*, Labaer,Joshua. Whole Genome and Transcriptome Sequencing Analyses of Desmoplastic Small Round Cell Tumors. PHX. CHILDREN'S HOSP(9/1/2012 - 9/30/2015).
Coletta,Dawn*, Dinu,Valentin, Mandarino,Lawrence, Meyer,Christian. Epigenetics and the Origin of Muscle Insulin Resistance in Humans. HHS-NIH-NIDDK(8/6/2012 - 7/31/2017).
Dinu,Valentin*. BOA: a Server of Integrated Biological Reference Annotations for Clinical and Life Science 'omics' Application. ASU-Mayo Seed Grant(1/1/2012 - 11/30/2013).
Dinu,Valentin*, Labaer,Joshua. Next Generation Genome Sequencing of Desmoplastic Small Round Cell Tumors. PHX CHLDRN'S HOSPITAL(8/23/2011 - 8/22/2013).
Dinu,Valentin*. NIH Sequence Data - Bioinformatics Service. HHS-NIH-NLM(1/1/2011 - 12/31/2011).
Labaer,Joshua*, Cheatham,Robert Lee, Dinu,Valentin, Dinu,Valentin, Magee,Dewey Mitchell, Wallstrom,Garrick L, Wallstrom,Garrick L. Integrated Biodosimetry System (IBiS) for High Throughput Medical Care After Radiologic and Nuclear Events. BARDA(12/17/2009 - 1/31/2016).
Dinu,Valentin*. Computational Design of Peptide Inhibitors for Class B G Protein-coupled Receptors. MAYO CLINIC SCOTTSDALE(1/1/2001 - 12/31/2010).

Courses

Fall 2019
Course Number	Course Title
BMI 484	Internship
BMD 502	Foundations BMI Methods I
BMI 560	Teachng Biomedical Informatics
BMI 584	Internship
BMI 590	Reading and Conference
BMI 593	Applied Project
BMI 595	Continuing Registration
BMI 790	Reading and Conference
BMI 792	Research
BMI 799	Dissertation

Summer 2019
Course Number	Course Title
BMI 484	Internship
BMI 584	Internship
BMI 792	Research

Spring 2019
Course Number	Course Title
BMI 484	Internship
BMI 493	Honors Thesis
BMI 550	Translational Bioinformatics
BMD 550	Translational Bioinformatics
BMI 560	Teachng Biomedical Informatics
BMI 590	Reading and Conference
BMI 593	Applied Project
BMI 790	Reading and Conference
BMI 792	Research
BMI 799	Dissertation

Fall 2018
Course Number	Course Title
BMI 461	Advanced Topics in BMI I
BMI 484	Internship
BMI 492	Honors Directed Study
BMI 502	Foundations BMI Methods I
BMD 502	Foundations BMI Methods I
BMI 560	Teachng Biomedical Informatics
BMI 584	Internship
BMI 590	Reading and Conference
BMI 593	Applied Project
BMI 790	Reading and Conference
BMI 792	Research
BMI 799	Dissertation

Summer 2018
Course Number	Course Title
BMI 484	Internship
BMI 584	Internship
BMI 595	Continuing Registration
BMI 792	Research

Spring 2018
Course Number	Course Title
BMI 484	Internship
BMI 493	Honors Thesis
BMI 499	Individualized Instruction
BMD 550	Translational Bioinformatics
BMI 550	Translational Bioinformatics
BMI 560	Teachng Biomedical Informatics
BMI 593	Applied Project
BMI 790	Reading and Conference
BMI 792	Research
BMI 799	Dissertation

Fall 2017
Course Number	Course Title
BMI 484	Internship
BMI 492	Honors Directed Study
BMI 499	Individualized Instruction
BMI 502	Foundations BMI Methods I
BMD 502	Foundations BMI Methods I
BMI 560	Teachng Biomedical Informatics
BMI 593	Applied Project
BMI 595	Continuing Registration
BMI 790	Reading and Conference
BMI 792	Research
BMI 799	Dissertation

Summer 2017
Course Number	Course Title
BMI 484	Internship
BMI 584	Internship
BMI 593	Applied Project
BMI 595	Continuing Registration
BMI 792	Research
BMI 799	Dissertation

Spring 2017
Course Number	Course Title
BMD 550	Translational Bioinformatics
BMI 550	Translational Bioinformatics
BMI 560	Teachng Biomedical Informatics
BMI 590	Reading and Conference
BMI 592	Research
BMI 593	Applied Project
BMI 595	Continuing Registration
BMI 790	Reading and Conference
BMI 792	Research
BMI 799	Dissertation

Fall 2016
Course Number	Course Title
BMD 502	Foundations BMI Methods I
BMI 502	Foundations BMI Methods I
BMI 560	Teachng Biomedical Informatics
BMI 593	Applied Project
BMI 595	Continuing Registration
BMI 790	Reading and Conference
BMI 792	Research

Summer 2016
Course Number	Course Title
BMI 790	Reading and Conference
BMI 792	Research

Spring 2016
Course Number	Course Title
BMI 592	Research
BMI 593	Applied Project
BMI 790	Reading and Conference
BMI 792	Research
BMI 799	Dissertation

Fall 2015
Course Number	Course Title
BMI 592	Research
BMI 593	Applied Project
BMI 790	Reading and Conference
BMI 792	Research

Summer 2015
Course Number	Course Title
BMI 790	Reading and Conference
BMI 792	Research

Spring 2015
Course Number	Course Title
BMI 592	Research
BMI 790	Reading and Conference
BMI 799	Dissertation

Presentations

Valentin Dinu. Pathway-based Analysis of Association between High Density Genomic Loci and Disease. Neuroscience-Neurogenomics Collaborative Colloquium Series (UA, TGen, ASU) (Nov 2008).
Jeffrey Kriseman, Tarek Saleh, Valentin Dinu. Next Generation Translational Bioinformatics Research Toolkit. Translational Genomics Research Institute Retreat (May 2008).
Dinu, Valentin. Pathway-based Analysis of Association between Genomic Loci and Disease. Mayo Clinic Seminar Series (Apr 2008).
Dinu, Valentin. Informatics Approaches to Translational Research: Management and Analysis of Clinical and High Density Genomic Data. (May 2007).
Dinu, Valentin. Integrating Domain Knowledge with Statistical and Data Mining Methods for High Density Genomic SNP Disease Association Analysis. (Apr 2007).
Dinu, Valentin. Pathway/SNP: Integrating Domain Knowledge with Statistical and Data Mining Methods for High Density Genomic SNP Disease Association Analysis. Genome-Wide Association Studies: Design and Analysis Conference (Oct 2006).
Dinu, Valentin. Pathway-based Analysis of Association between Genomic Loci and Disease. NLM Informatics Training Conference (Jun 2006).

Honors/Awards

Excellence in Teaching Award (1999)
Magna Cum Laude with Highest Honors college graduate (2000)
PhD funded by National Library of Medicine Biomedical Informatics Training Grant (2004-2007)
ASU/Mayo Clinic Partnership for Collaborative Research Seed Grant Award (2010)

Service

Human Genetics, Research Article Reviewer (2008 - Present)
BMI/BMS Colloquium Series Committee, Member (2008 - Present)
Journal of Biomedical Informatics, Research Article Reviewer (2008 - Present)
BMI Undergraduate Curriculum Committee, (2007 - Present)
BMI Graduate Curriculum Committee, (2007 - Present)
EURASIP Journal on Bioinformatics and Systems Biology, Research Article Reviewer (2007 - Present)
BMI Adjunct/Affiliate Committee, Chair (2008 - 2008)