Department of Biomedical Informatics

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Implementation of a Research Patient Data Repository at Phoenix Children’s Hospital

Research Topic: 
Bioinformatics
Personnel: 
Graciela Gonzalez
Robert Greenes

Aggregated, disease-specific clinical data is a valuable resource for researchers and clinicians to determine research study feasibility, assess patient care quality, and, when linked to patient-specific data, aid in clinical trial recruitment. In this proposal, we will adapt, implement and evaluate the i2b2 Workbench, developed at Harvard -Partners National Center for Biomedical Computing, to create a pediatric research patient data repository (RPDR) at Phoenix Children’s hospital. We will formally assess the quality of the data found in the RPDR by comparing the RPDR data to a manual review of medical charts for two neurologic diseases - anti-epileptic drug therapy and intractable seizures. If the pilot implementation is successful, the modular nature of the i2b2 framework will allow rapid extension of the tool to other disease-specific data at PCH and serve as a model for other patient data repository initiatives.