Department of Biomedical Informatics

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Epigenetics and the Origin of Muscle Insulin Resistance in Humans

Research Topic: 
Bioinformatics
Personnel: 
Valentin Dinu
Dawn Coletta (ASU/Mayo Center for Metabolic and Vascular Biology)
Larry Mandarino (ASU/Mayo Center for Metabolic and Vascular Biology)

The goal is to explore global patterns of changes in DNA methylation in metabolically well-characterized insulin sensitive and resistant individuals and to determine whether these changes can explain alterations in gene expression and protein abundance in insulin resistance associated with obesity and type 2 diabetes.

Timeline:

2012 - current