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My research has been primarily focused on exploring the effects of a novel, high-intensity interval exercise paradigm on cardiovascular and metabolic physiology in severe chronic diseases such as congestive heart failure and cardiac toxicity in breast cancer survivors. I specifically utilize exercise training as a pleiotropic “drug” to modify the disease process and to understand the mechanisms of disease in individuals suffering from these conditions. Furthermore, I have also been involved in the development of a novel risk score (utilizing peak oxygen uptake) for predicting the risk of major adverse cardiovascular events in patients with end-stage renal disease undergoing renal transplantation.
Heart failure is a major worldwide health concern and is the leading cause of hospitalization among elderly Americans. Approximately 50% of those diagnosed with heart failure have heart failure with preserved ejection fraction (HFPEF). HFPEF presents a therapeutic dilemma because pharmacological strategies that are effective for the treatment of heart failure and reduced ejection fraction have failed to show benefit in HFPEF. Aerobic exercise is an emergent treatment modality that may help improve left ventricular diastolic function in these patients. My research focuses principally on the effects of exercise intensity on markers of diastolic dysfunction and vascular function in patients with heart failure and preserved ejection fraction.
1. Angadi SS and Gaesser GA. Pre-exercise cardiology screening guidelines for asymptomatic patients with diabetes. Clin Sports Med. 2009;28:379-92. IF - 1.22.
2. Angadi SS, Weltman A, Watson-Winfield D, Weltman J, Frick K, Patrie J and Gaesser GA. Effect of fractionized vs continuous, single-session exercise on blood pressure in adults. J Hum Hypertens. 2010;24:300-2. IF - 2.7
3. Gaesser GA and Angadi SS. High-intensity interval training for health and fitness: can less be more? J Appl Physiol (1985). 2011;111:1540-1. IF - 3.056
4. Gaesser GA, Angadi SS and Sawyer BJ. Exercise and diet, independent of weight loss, improve cardiometabolic risk profile in overweight and obese individuals. Phys Sportsmed. 2011;39:87-97. IF - 1.49
5. Rynders CA, Angadi SS, Weltman NY, Gaesser GA and Weltman A. Oxygen uptake and ratings of perceived exertion at the lactate threshold and maximal fat oxidation rate in untrained adults. Eur J Appl Physiol. 2011;111:2063-8. IF - 2.187
6. Bhammar DM, Angadi SS and Gaesser GA. Effects of fractionized and continuous exercise on 24-h ambulatory blood pressure. Med Sci Sports Exerc. 2012;44:2270-6. IF - 4.459
7. Gaesser GA and Angadi SS. Gluten-free diet: imprudent dietary advice for the general population? J Acad Nutr Diet. 2012;112:1330-3. IF - 2.444
8. Gaesser GA, Angadi SS, Ryan DM and Johnston CS. Lifestyle Measures to Reduce Inflammation. American Journal of Lifestyle Medicine. 2012;6:4-13. IF - 0.8
9. Herrmann SD and Angadi SS. Children's physical activity and sedentary time and cardiometabolic risk factors. Clin J Sport Med. 2013;23:408-9. IF - 2.268
10. Pesta DH, Angadi SS, Burtscher M and Roberts CK. The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance. Nutr Metab (Lond). 2013;10:71. IF - 3.26
11. Roberts CK, Izadpanah A, Angadi SS and Barnard RJ. Effects of an intensive short-term diet and exercise intervention: comparison between normal-weight and obese children. Am J Physiol Regul Integr Comp Physiol. 2013;305:R552-7. IF - 3.106
12. Angadi SS, Bhammar DM and Gaessser GA. Postexercise hypotension after continuous, aerobic interval, and sprint interval exercise. J Strength Cond Res. 2015. IF - 2.075
13. Angadi SS, Mookadam F, Lee CD, Tucker WJ, Haykowsky MJ and Gaesser GA. High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: a pilot study. J Appl Physiol (1985). 2015;119:753-8. IF - 3.056
14. Gaesser GA and Angadi SS. Navigating the gluten-free boom. JAAPA. 2015;28:1-7.
15. Gaesser GA, Tucker WJ, Jarrett CL and Angadi SS. Fitness versus Fatness: Which Influences Health and Mortality Risk the Most? Curr Sports Med Rep. 2015;14:327-32. IF - 1.552
16. Hurley JC, Hollingshead KE, Todd M, Jarrett CL, Tucker WJ, Angadi SS and Adams MA. The Walking Interventions Through Texting (WalkIT) Trial: Rationale, Design, and Protocol for a Factorial Randomized Controlled Trial of Adaptive Interventions for Overweight and Obese, Inactive Adults. JMIR Res Protoc. 2015;4:e108. IF - 4.663
17. Roberts CK, Lee MM, Katiraie M, Krell SL, Angadi SS, Chronley MK, Oh CS, Ribas V, Harris RA, Hevener AL and Croymans DM. Strength fitness and body weight status on markers of cardiometabolic health. Med Sci Sports Exerc. 2015;47:1211-8. IF - 4.459
18. Sawyer BJ, Bhammar DM, Angadi SS, Ryan DM, Ryder JR, Sussman EJ, Bertmann FM and Gaesser GA. Predictors of fat mass changes in response to aerobic exercise training in women. J Strength Cond Res. 2015;29:297-304. IF - 2.075
19. Contractor A, Bhanushali A, Changrani J, Angadi S and Das BR. Pedometer assessed physical activity in urban pubertal children: first report from India. J Phys Act Health. 2014;11:1475-81. IF - 1.854
20. Tucker WJ, Angadi SS, Gaesser GA. Excess postexercise oxygen consumption after high-intensity and sprint interval exercise, and continuous steady-state exercise. J Strength Cond Res. 2016 Mar 3. [Epub ahead of print]