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Haiwei Gu's research interests focus on MS-based metabolomics and its applications in early disease diagnosis, drug metabolism, and biological sciences. He is working closely with a number of biological researchers and clinical practitioners in various studies for identifying metabolic markers, which are useful for detecting cancers, investigating cancer mechanisms using cell/mitochondria models, examining metabolic remodeling during pressure-overload hypertrophy, comprehensively profiling age-dependent changes of cardiac metabolites, etc. Gu is an assistant professor in the College of Health Solutions at Arizona State University.
The Gu research group focuses on mass spectrometry (MS)-based metabolomics and its applications for biomarker discovery and systems biology research. We are skilled in the development, optimization, and applications of MS methods for both qualitative and quantitative measurements. We utilize a range of platforms, including LC- and GC-MS for global aqueous profiling and lipidomics. We have developed a number of targeted LC-MS/MS assays to detect panels of metabolites, including a 200+ aqueous metabolite assay that interrogates 35 metabolic pathways, as well as assays to measure bile acids, acyl carnitines, co-enzymes, and cardiolipins. Recent methods developed by our group include quantitative methods to measure metabolite concentrations, metabolic flux analysis approaches, and ratio analysis methods for unknown identification. In addition, we have extensive experience with advanced multivariate statistical analysis methods, including PCA, PLS-DA, SVM, etc. We can proficiently program in Matlab, R, and Pathyn to analyze MS and NMR data, both individually and in combination.
In addition to our methods development activities, we are working closely with a number of biological researchers and clinical practitioners in various studies. We have been active in the identification of biomarkers for early cancer detection, recurrence monitoring, and therapy prediction. We are also involved in studies of heart diseases, obesity, and diabetes, as well as nutrition based disease prevention and aging. Our group has a strong interest in expanding the understanding of disease risk factors using metabolite profiling approaches. My group has experience running large metabolomics sample sets that incorporate a number of quality control measures to ensure reliability of large datasets. Our work in metabolomics is thus applied to a broad range of applications in both basic and clinical metabolic research.
Spring 2021 | |
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Course Number | Course Title |
BIO 495 | Undergraduate Research |
MBB 495 | Undergraduate Research |
EXW 501 | Research Statistics |
NTR 599 | Thesis |
NTR 692 | Research |
NTR 780 | Practicum |
NTR 792 | Research |
NTR 799 | Dissertation |
Fall 2020 | |
---|---|
Course Number | Course Title |
CHS 494 | Special Topics |
MBB 495 | Undergraduate Research |
CHS 499 | Individualized Instruction |
EXW 501 | Research Statistics |
NTR 599 | Thesis |
NTR 692 | Research |
NTR 792 | Research |
NTR 799 | Dissertation |
Summer 2020 | |
---|---|
Course Number | Course Title |
CHS 494 | Special Topics |
NTR 599 | Thesis |
NTR 692 | Research |
NTR 792 | Research |
NTR 799 | Dissertation |
Spring 2020 | |
---|---|
Course Number | Course Title |
HCD 300 | Biostatistics |
CHS 493 | Honors Thesis |
CHS 494 | Special Topics |
BIO 495 | Undergraduate Research |
MBB 495 | Undergraduate Research |
EXW 501 | Research Statistics |
NTR 599 | Thesis |
NTR 692 | Research |
NTR 780 | Practicum |
NTR 792 | Research |
NTR 799 | Dissertation |
Fall 2019 | |
---|---|
Course Number | Course Title |
HCD 300 | Biostatistics |
CHS 492 | Honors Directed Study |
MBB 495 | Undergraduate Research |
EXW 501 | Research Statistics |
NTR 599 | Thesis |
NTR 692 | Research |
NTR 792 | Research |
NTR 799 | Dissertation |
Summer 2019 | |
---|---|
Course Number | Course Title |
NTR 499 | Individualized Instruction |
NTR 599 | Thesis |
NTR 692 | Research |
NTR 792 | Research |
Spring 2019 | |
---|---|
Course Number | Course Title |
NTR 492 | Honors Directed Study |
NTR 493 | Honors Thesis |
NTR 499 | Individualized Instruction |
EXW 501 | Research Statistics |
NTR 599 | Thesis |
EXW 692 | Research |
EXW 792 | Research |
EXW 799 | Dissertation |
Fall 2018 | |
---|---|
Course Number | Course Title |
NTR 492 | Honors Directed Study |
NTR 499 | Individualized Instruction |
Summer 2018 | |
---|---|
Course Number | Course Title |
NTR 499 | Individualized Instruction |
NTR 692 | Research |
NTR 792 | Research |
Spring 2018 | |
---|---|
Course Number | Course Title |
NTR 598 | Special Topics |
EXW 692 | Research |
EXW 792 | Research |
EXW 799 | Dissertation |
Course Number NTR 598
Course Title Nutrition and Food Metabolomics
Credits 3